diff --git a/bindings/python/Cargo.toml b/bindings/python/Cargo.toml
index a92d7362..45e040ce 100644
--- a/bindings/python/Cargo.toml
+++ b/bindings/python/Cargo.toml
@@ -10,12 +10,12 @@ crate-type = ["cdylib"]
 
 [dependencies]
 rayon = "1.10"
-serde = { version = "1.0", features = [ "rc", "derive" ]}
+serde = { version = "1.0", features = ["rc", "derive"] }
 serde_json = "1.0"
 libc = "0.2"
 env_logger = "0.11"
-pyo3 = { version = "0.21" }
-numpy = "0.21"
+pyo3 = { version = "0.22", features = ["py-clone"] }
+numpy = "0.22"
 ndarray = "0.15"
 itertools = "0.12"
 
@@ -24,7 +24,7 @@ path = "../../tokenizers"
 
 [dev-dependencies]
 tempfile = "3.10"
-pyo3 = { version = "0.21", features = ["auto-initialize"] }
+pyo3 = { version = "0.22", features = ["auto-initialize", "py-clone"] }
 
 [features]
 defaut = ["pyo3/extension-module"]
diff --git a/bindings/python/src/decoders.rs b/bindings/python/src/decoders.rs
index 1a03a772..ab4ac066 100644
--- a/bindings/python/src/decoders.rs
+++ b/bindings/python/src/decoders.rs
@@ -88,9 +88,9 @@ impl PyDecoder {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.decoder = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.decoder = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle Decoder: {}",
                         e
diff --git a/bindings/python/src/encoding.rs b/bindings/python/src/encoding.rs
index 3ca48d56..9d7fbde7 100644
--- a/bindings/python/src/encoding.rs
+++ b/bindings/python/src/encoding.rs
@@ -41,9 +41,9 @@ impl PyEncoding {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.encoding = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.encoding = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle Encoding: {}",
                         e
diff --git a/bindings/python/src/models.rs b/bindings/python/src/models.rs
index 424be9f5..91b8fe1b 100644
--- a/bindings/python/src/models.rs
+++ b/bindings/python/src/models.rs
@@ -109,9 +109,9 @@ impl PyModel {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.model = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.model = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle Model: {}",
                         e
@@ -181,7 +181,7 @@ impl PyModel {
     ///
     /// Returns:
     ///     :obj:`List[str]`: The list of saved files
-    #[pyo3(text_signature = "(self, folder, prefix)")]
+    #[pyo3(signature = (folder, prefix=None, name=None), text_signature = "(self, folder, prefix)")]
     fn save<'a>(
         &self,
         py: Python<'_>,
@@ -835,7 +835,7 @@ pub struct PyUnigram {}
 #[pymethods]
 impl PyUnigram {
     #[new]
-    #[pyo3(text_signature = "(self, vocab, unk_id, byte_fallback)")]
+    #[pyo3(signature = (vocab=None, unk_id=None, byte_fallback=None), text_signature = "(self, vocab, unk_id, byte_fallback)")]
     fn new(
         vocab: Option<Vec<(String, f64)>>,
         unk_id: Option<usize>,
diff --git a/bindings/python/src/normalizers.rs b/bindings/python/src/normalizers.rs
index feff9811..7b592690 100644
--- a/bindings/python/src/normalizers.rs
+++ b/bindings/python/src/normalizers.rs
@@ -118,9 +118,9 @@ impl PyNormalizer {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.normalizer = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.normalizer = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle Normalizer: {}",
                         e
diff --git a/bindings/python/src/pre_tokenizers.rs b/bindings/python/src/pre_tokenizers.rs
index 1c43f7eb..92a40fc7 100644
--- a/bindings/python/src/pre_tokenizers.rs
+++ b/bindings/python/src/pre_tokenizers.rs
@@ -122,9 +122,9 @@ impl PyPreTokenizer {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                let unpickled = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                let unpickled = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle PreTokenizer: {}",
                         e
diff --git a/bindings/python/src/processors.rs b/bindings/python/src/processors.rs
index 1d8e8dfa..474f1e8f 100644
--- a/bindings/python/src/processors.rs
+++ b/bindings/python/src/processors.rs
@@ -82,9 +82,9 @@ impl PyPostProcessor {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.processor = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.processor = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle PostProcessor: {}",
                         e
@@ -272,7 +272,7 @@ impl From<PySpecialToken> for SpecialToken {
 }
 
 impl FromPyObject<'_> for PySpecialToken {
-    fn extract(ob: &PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'_, PyAny>) -> PyResult<Self> {
         if let Ok(v) = ob.extract::<(String, u32)>() {
             Ok(Self(v.into()))
         } else if let Ok(v) = ob.extract::<(u32, String)>() {
@@ -312,7 +312,7 @@ impl From<PyTemplate> for Template {
 }
 
 impl FromPyObject<'_> for PyTemplate {
-    fn extract(ob: &PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'_, PyAny>) -> PyResult<Self> {
         if let Ok(s) = ob.extract::<&str>() {
             Ok(Self(
                 s.try_into().map_err(exceptions::PyValueError::new_err)?,
diff --git a/bindings/python/src/tokenizer.rs b/bindings/python/src/tokenizer.rs
index 00dacf41..7fd03ae8 100644
--- a/bindings/python/src/tokenizer.rs
+++ b/bindings/python/src/tokenizer.rs
@@ -2,7 +2,7 @@ use serde::Serialize;
 use std::collections::{hash_map::DefaultHasher, HashMap};
 use std::hash::{Hash, Hasher};
 
-use numpy::{npyffi, PyArray1};
+use numpy::{npyffi, PyArray1, PyArrayMethods};
 use pyo3::class::basic::CompareOp;
 use pyo3::exceptions;
 use pyo3::intern;
@@ -156,7 +156,7 @@ impl PyAddedToken {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyDict>(py) {
+        match state.downcast_bound::<PyDict>(py) {
             Ok(state) => {
                 for (key, value) in state {
                     let key: &str = key.extract()?;
@@ -172,7 +172,7 @@ impl PyAddedToken {
                 }
                 Ok(())
             }
-            Err(e) => Err(e),
+            Err(e) => Err(e.into()),
         }
     }
 
@@ -263,10 +263,10 @@ impl PyAddedToken {
 
 struct TextInputSequence<'s>(tk::InputSequence<'s>);
 impl<'s> FromPyObject<'s> for TextInputSequence<'s> {
-    fn extract(ob: &'s PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'s, PyAny>) -> PyResult<Self> {
         let err = exceptions::PyTypeError::new_err("TextInputSequence must be str");
-        if let Ok(s) = ob.downcast::<PyString>() {
-            Ok(Self(s.to_string_lossy().into()))
+        if let Ok(s) = ob.extract::<String>() {
+            Ok(Self(s.into()))
         } else {
             Err(err)
         }
@@ -280,7 +280,7 @@ impl<'s> From<TextInputSequence<'s>> for tk::InputSequence<'s> {
 
 struct PyArrayUnicode(Vec<String>);
 impl FromPyObject<'_> for PyArrayUnicode {
-    fn extract(ob: &PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'_, PyAny>) -> PyResult<Self> {
         // SAFETY Making sure the pointer is a valid numpy array requires calling numpy C code
         if unsafe { npyffi::PyArray_Check(ob.py(), ob.as_ptr()) } == 0 {
             return Err(exceptions::PyTypeError::new_err("Expected an np.array"));
@@ -291,8 +291,8 @@ impl FromPyObject<'_> for PyArrayUnicode {
             let desc = (*arr).descr;
             (
                 (*desc).type_num,
-                (*desc).elsize as usize,
-                (*desc).alignment as usize,
+                npyffi::PyDataType_ELSIZE(ob.py(), desc) as usize,
+                npyffi::PyDataType_ALIGNMENT(ob.py(), desc) as usize,
                 (*arr).data,
                 (*arr).nd,
                 (*arr).flags,
@@ -347,7 +347,7 @@ impl From<PyArrayUnicode> for tk::InputSequence<'_> {
 
 struct PyArrayStr(Vec<String>);
 impl FromPyObject<'_> for PyArrayStr {
-    fn extract(ob: &PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'_, PyAny>) -> PyResult<Self> {
         let array = ob.downcast::<PyArray1<PyObject>>()?;
         let seq = array
             .readonly()
@@ -370,7 +370,7 @@ impl From<PyArrayStr> for tk::InputSequence<'_> {
 
 struct PreTokenizedInputSequence<'s>(tk::InputSequence<'s>);
 impl<'s> FromPyObject<'s> for PreTokenizedInputSequence<'s> {
-    fn extract(ob: &'s PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'s, PyAny>) -> PyResult<Self> {
         if let Ok(seq) = ob.extract::<PyArrayUnicode>() {
             return Ok(Self(seq.into()));
         }
@@ -400,17 +400,17 @@ impl<'s> From<PreTokenizedInputSequence<'s>> for tk::InputSequence<'s> {
 
 struct TextEncodeInput<'s>(tk::EncodeInput<'s>);
 impl<'s> FromPyObject<'s> for TextEncodeInput<'s> {
-    fn extract(ob: &'s PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'s, PyAny>) -> PyResult<Self> {
         if let Ok(i) = ob.extract::<TextInputSequence>() {
             return Ok(Self(i.into()));
         }
         if let Ok((i1, i2)) = ob.extract::<(TextInputSequence, TextInputSequence)>() {
             return Ok(Self((i1, i2).into()));
         }
-        if let Ok(arr) = ob.extract::<Vec<&PyAny>>() {
+        if let Ok(arr) = ob.downcast::<PyList>() {
             if arr.len() == 2 {
-                let first = arr[0].extract::<TextInputSequence>()?;
-                let second = arr[1].extract::<TextInputSequence>()?;
+                let first = arr.get_item(0)?.extract::<TextInputSequence>()?;
+                let second = arr.get_item(1)?.extract::<TextInputSequence>()?;
                 return Ok(Self((first, second).into()));
             }
         }
@@ -426,7 +426,7 @@ impl<'s> From<TextEncodeInput<'s>> for tk::tokenizer::EncodeInput<'s> {
 }
 struct PreTokenizedEncodeInput<'s>(tk::EncodeInput<'s>);
 impl<'s> FromPyObject<'s> for PreTokenizedEncodeInput<'s> {
-    fn extract(ob: &'s PyAny) -> PyResult<Self> {
+    fn extract_bound(ob: &Bound<'s, PyAny>) -> PyResult<Self> {
         if let Ok(i) = ob.extract::<PreTokenizedInputSequence>() {
             return Ok(Self(i.into()));
         }
@@ -434,10 +434,10 @@ impl<'s> FromPyObject<'s> for PreTokenizedEncodeInput<'s> {
         {
             return Ok(Self((i1, i2).into()));
         }
-        if let Ok(arr) = ob.extract::<Vec<&PyAny>>() {
+        if let Ok(arr) = ob.downcast::<PyList>() {
             if arr.len() == 2 {
-                let first = arr[0].extract::<PreTokenizedInputSequence>()?;
-                let second = arr[1].extract::<PreTokenizedInputSequence>()?;
+                let first = arr.get_item(0)?.extract::<PreTokenizedInputSequence>()?;
+                let second = arr.get_item(1)?.extract::<PreTokenizedInputSequence>()?;
                 return Ok(Self((first, second).into()));
             }
         }
@@ -498,9 +498,9 @@ impl PyTokenizer {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                self.tokenizer = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                self.tokenizer = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle Tokenizer: {}",
                         e
@@ -1030,7 +1030,7 @@ impl PyTokenizer {
     fn encode_batch(
         &self,
         py: Python<'_>,
-        input: Vec<&PyAny>,
+        input: Bound<'_, PyList>,
         is_pretokenized: bool,
         add_special_tokens: bool,
     ) -> PyResult<Vec<PyEncoding>> {
@@ -1091,7 +1091,7 @@ impl PyTokenizer {
     fn encode_batch_fast(
         &self,
         py: Python<'_>,
-        input: Vec<&PyAny>,
+        input: Bound<'_, PyList>,
         is_pretokenized: bool,
         add_special_tokens: bool,
     ) -> PyResult<Vec<PyEncoding>> {
diff --git a/bindings/python/src/trainers.rs b/bindings/python/src/trainers.rs
index c7144229..d4c7e615 100644
--- a/bindings/python/src/trainers.rs
+++ b/bindings/python/src/trainers.rs
@@ -55,9 +55,9 @@ impl PyTrainer {
     }
 
     fn __setstate__(&mut self, py: Python, state: PyObject) -> PyResult<()> {
-        match state.extract::<&PyBytes>(py) {
+        match state.extract::<&[u8]>(py) {
             Ok(s) => {
-                let unpickled = serde_json::from_slice(s.as_bytes()).map_err(|e| {
+                let unpickled = serde_json::from_slice(s).map_err(|e| {
                     exceptions::PyException::new_err(format!(
                         "Error while attempting to unpickle PyTrainer: {}",
                         e
diff --git a/bindings/python/src/utils/normalization.rs b/bindings/python/src/utils/normalization.rs
index b67dcff9..107d0a27 100644
--- a/bindings/python/src/utils/normalization.rs
+++ b/bindings/python/src/utils/normalization.rs
@@ -60,7 +60,7 @@ pub enum PyRange<'s> {
     #[pyo3(annotation = "Tuple[uint, uint]")]
     Range(usize, usize),
     #[pyo3(annotation = "slice")]
-    Slice(&'s PySlice),
+    Slice(Bound<'s, PySlice>),
 }
 impl PyRange<'_> {
     pub fn to_range(&self, max_len: usize) -> PyResult<std::ops::Range<usize>> {
@@ -83,7 +83,7 @@ impl PyRange<'_> {
             }
             PyRange::Range(s, e) => Ok(*s..*e),
             PyRange::Slice(s) => {
-                let r = s.indices(max_len as std::os::raw::c_long)?;
+                let r = s.indices(max_len.try_into()?)?;
                 Ok(r.start as usize..r.stop as usize)
             }
         }
@@ -94,7 +94,7 @@ impl PyRange<'_> {
 pub struct PySplitDelimiterBehavior(pub SplitDelimiterBehavior);
 
 impl FromPyObject<'_> for PySplitDelimiterBehavior {
-    fn extract(obj: &PyAny) -> PyResult<Self> {
+    fn extract_bound(obj: &Bound<'_, PyAny>) -> PyResult<Self> {
         let s = obj.extract::<&str>()?;
 
         Ok(Self(match s {
diff --git a/bindings/python/src/utils/pretokenization.rs b/bindings/python/src/utils/pretokenization.rs
index 70444aac..a9879ad9 100644
--- a/bindings/python/src/utils/pretokenization.rs
+++ b/bindings/python/src/utils/pretokenization.rs
@@ -56,7 +56,7 @@ fn tokenize(pretok: &mut PreTokenizedString, func: &Bound<'_, PyAny>) -> PyResul
         ToPyResult(pretok.tokenize(|normalized| {
             let output = func.call((normalized.get(),), None)?;
             Ok(output
-                .extract::<&PyList>()?
+                .extract::<Bound<PyList>>()?
                 .into_iter()
                 .map(|obj| Ok(Token::from(obj.extract::<PyToken>()?)))
                 .collect::<PyResult<Vec<_>>>()?)
@@ -69,7 +69,7 @@ fn tokenize(pretok: &mut PreTokenizedString, func: &Bound<'_, PyAny>) -> PyResul
 #[derive(Clone)]
 pub struct PyOffsetReferential(OffsetReferential);
 impl FromPyObject<'_> for PyOffsetReferential {
-    fn extract(obj: &PyAny) -> PyResult<Self> {
+    fn extract_bound(obj: &Bound<'_, PyAny>) -> PyResult<Self> {
         let s = obj.extract::<&str>()?;
 
         Ok(Self(match s {
@@ -85,7 +85,7 @@ impl FromPyObject<'_> for PyOffsetReferential {
 #[derive(Clone)]
 pub struct PyOffsetType(OffsetType);
 impl FromPyObject<'_> for PyOffsetType {
-    fn extract(obj: &PyAny) -> PyResult<Self> {
+    fn extract_bound(obj: &Bound<'_, PyAny>) -> PyResult<Self> {
         let s = obj.extract::<&str>()?;
 
         Ok(Self(match s {